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People are more susceptible if they are taking medications that prevent normal blood clotting. Other predisposing factors include infection, trauma, allergic and non-allergic rhinitis, hypertension, alcohol abuse, and inherited bleeding problems.

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The bile pigment, bilirubin, comes from red blood cells. When old red blood cells are destroyed by the body, the oxygen-carrying molecule within the cells, hemoglobin, is released into the blood. The hemoglobin is rapidly converted to bilirubin in the blood. The bilirubin is removed from the blood by the liver, modified, and excreted into the bile. The bile flows into the intestine so that the bilirubin is eliminated in the stool.

In recent years investigators have found that negative square waves are much more effective than AC. For the past several years, pain centers in the U.S. have been conducting clinical studies on the analgesic effect of negative pulse stimulation. The results have been encouraging, negative pulse stimulation is now recognized as a common therapy for pain.

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